A pet chameleon named Rango, grew up in a terrarium from early childhood. The owners took care of their pet, doing everything to make him feel comfortable. The main character has always dreamed of adventures, but life behind glass walls did not give him the opportunity to make dreams come true. Once people took a pet with them on a short trip by car.

During the movement, the lizard's dwelling fell out, and he was free. Soon, the terrified Rango managed to get to a small town located in a desert area, where various animals live. Thanks to a "happy" coincidence, a newly minted citizen becomes a sheriff. Standing up for the law, he did not anticipate what troubles he would face in the near future. In addition to the problems associated with the lack of life-giving moisture, the guardian of order must resolve the issue with the dangerous bandit rattlesnake Jake, terrorizing residents.