The owner of Tom is going to move to a new place of residence, as the house will soon be demolished to free up the territory for the construction of a huge skyscraper. Not wanting to be left without a roof over his head, quick-witted Jerry intends to move with old acquaintances. As a result of unforeseen circumstances, the main characters did not have time to jump into a truck carrying things, so they were forced to spend the night in an empty mansion. In the morning, the building was demolished, and the friends went to wander the streets of the big city.

Soon they meet a stray dog named Puggsy and his flea buddy Frankie, who are trying to convince the couple to make friends in order to survive in difficult conditions. After some time, Jerry and Tom meet an orphan girl, Robin Starling, who dreams of making a trip to Tibet. According to rumors, it was there that the girl's father died. She now lives with her Aunt Figg, an extremely unpleasant woman. Aunt takes care of her niece solely because of money, because her dad is a billionaire. Imbued with the story of a young person, friends decide to bring her home. When it turned out that Starling Sr. was alive, Figg tried to burn the letter, but the mouse managed to save the message...